Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia.

A novel resistant variant of murine P388 leukaemia, P388/SPR, was identified by de novo resistance to doxorubicin (DOX) in vivo. This mutant displayed a similar level of cross-resistance to etoposide (VP-16) and other topoisomerase II (topo II) inhibitors. Further analysis of the phenotype revealed...

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Detalles Bibliográficos
Autores principales: Kühl, J. S., Krajewski, S., Durán, G. E., Reed, J. C., Sikic, B. I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063280/
https://www.ncbi.nlm.nih.gov/pubmed/9010037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063280/
https://www.ncbi.nlm.nih.gov/pubmed/9010037

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