Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA.

5'-Deoxy-5-fluorouridine (5'-DFUR) and 1-(tetrahydro-2-furyl)-5-fluorouracil (tegafur), prodrugs of 5-fluorouracil (5-FU), are anticancer agents activated by thymidine phosphorylase (dThdPase). As it is well known that the levels of dThdPase are higher in tumours than in normal tissue, it...

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Detalles Bibliográficos
Autores principales: Kato, Y., Matsukawa, S., Muraoka, R., Tanigawa, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group|1 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063296/
https://www.ncbi.nlm.nih.gov/pubmed/9052401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063296/
https://www.ncbi.nlm.nih.gov/pubmed/9052401

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