Cargando…
p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling
p53 is a well known tumor suppressor. We show that p53 also regulates osteoblast differentiation, bone formation, and osteoblast-dependent osteoclast differentiation. Indeed, p53 (−) (/) (−) mice display a high bone mass phenotype, and p53 (−) (/) (−) osteoblasts show accelerated differentiation, se...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063539/ https://www.ncbi.nlm.nih.gov/pubmed/16380437 http://dx.doi.org/10.1083/jcb.200507106 |