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Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP
The second messenger cyclic adenosine monophosphate (cAMP) plays a pivotal role in axonal growth and guidance, but its downstream mechanisms remain elusive. In this study, we report that type II protein kinase A (PKA) is highly enriched in growth cone filopodia, and this spatial localization enables...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063631/ https://www.ncbi.nlm.nih.gov/pubmed/17200417 http://dx.doi.org/10.1083/jcb.200607128 |