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Adaptation and increased susceptibility to infection associated with constitutive expression of misfolded SP-C
Mutations in the gene encoding SP-C (surfactant protein C; SFTPC) have been linked to interstitial lung disease (ILD) in children and adults. Expression of the index mutation, SP-C(Δexon4), in transiently transfected cells and type II cells of transgenic mice resulted in misfolding of the proprotein...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2006
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063649/ https://www.ncbi.nlm.nih.gov/pubmed/16449190 http://dx.doi.org/10.1083/jcb.200508016 |