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RGMa inhibition promotes axonal growth and recovery after spinal cord injury

Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of...

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Detalles Bibliográficos
Autores principales: Hata, Katsuhiko, Fujitani, Masashi, Yasuda, Yuichi, Doya, Hideo, Saito, Tomoko, Yamagishi, Satoru, Mueller, Bernhard K., Yamashita, Toshihide
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063787/
https://www.ncbi.nlm.nih.gov/pubmed/16585268
http://dx.doi.org/10.1083/jcb.200508143