Cargando…

RGMa inhibition promotes axonal growth and recovery after spinal cord injury

Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hata, Katsuhiko, Fujitani, Masashi, Yasuda, Yuichi, Doya, Hideo, Saito, Tomoko, Yamagishi, Satoru, Mueller, Bernhard K., Yamashita, Toshihide
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063787/ https://www.ncbi.nlm.nih.gov/pubmed/16585268 http://dx.doi.org/10.1083/jcb.200508143

Ejemplares similares

Activated Microglia Inhibit Axonal Growth through RGMa
por: Kitayama, Mari, et al.
Publicado: (2011)

The roles of RGMa-neogenin signaling in inflammation and angiogenesis
por: Fujita, Yuki, et al.
Publicado: (2017)

Humanized Anti-RGMa Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune Encephalomyelitis in Mice
por: Hirata, Takeshi, et al.
Publicado: (2022)

Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica
por: Harada, Kana, et al.
Publicado: (2018)

RGMa inhibition with human monoclonal antibodies promotes regeneration, plasticity and repair, and attenuates neuropathic pain after spinal cord injury
por: Mothe, Andrea J., et al.
Publicado: (2017)

RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS
por: Shimizu, Mikito, et al.
Publicado: (2023)

Strategies for regenerating injured axons after spinal cord injury – insights from brain development
por: Ueno, Masaki, et al.
Publicado: (2008)

RGMa Regulates Cortical Interneuron Migration and Differentiation
por: O'Leary, Conor, et al.
Publicado: (2013)

Promoting functions of microRNA-29a/199B in neurological recovery in rats with spinal cord injury through inhibition of the RGMA/STAT3 axis
por: Yang, Weijie, et al.
Publicado: (2020)

Elevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma
por: Phan, Thi Le, et al.
Publicado: (2021)

An antibody to RGMa promotes regeneration of cochlear synapses after noise exposure
por: Nevoux, Jerome, et al.
Publicado: (2021)

Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury
por: Nakanishi, Toru, et al.
Publicado: (2019)

Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis
por: Fujitani, Masashi, et al.
Publicado: (2017)

Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice
por: Miyajima, Hisao, et al.
Publicado: (2021)

Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury
por: Meves, Jessica M., et al.
Publicado: (2014)

Inosine Enhances Axon Sprouting and Motor Recovery after Spinal Cord Injury
por: Kim, Daniel, et al.
Publicado: (2013)

Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury
por: Ishii, H, et al.
Publicado: (2012)

Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury
por: Zhang, Suxiang, et al.
Publicado: (2018)

Ecto-domain phosphorylation promotes functional recovery from spinal cord injury
por: Suehiro, Kenji, et al.
Publicado: (2014)

Reorganization of Corticospinal Projections after Prominent Recovery of Finger Dexterity from Partial Spinal Cord Injury in Macaque Monkeys
por: Sawada, Masahiro, et al.
Publicado: (2023)

Silencing miR‐20a‐5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa‐RhoA‐mediated synaptic plasticity
por: Feng, Yanyan, et al.
Publicado: (2020)

The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex
por: Zhang, Suxiang, et al.
Publicado: (2014)

Protocol for Co-culture of Microglia with Axons
por: Fujita, Yuki, et al.
Publicado: (2020)

Corrigendum: Ecto-domain phosphorylation promotes functional recovery from spinal cord injury
por: Suehiro, Kenji, et al.
Publicado: (2015)

Transcriptomic characterization of the molecular mechanisms induced by RGMa during skeletal muscle nuclei accretion and hypertrophy
por: Copola, Aline Gonçalves Lio, et al.
Publicado: (2022)

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders
por: Fujitani, Masashi, et al.
Publicado: (2021)

Axonal regeneration in zebrafish spinal cord
por: Ghosh, Sukla, et al.
Publicado: (2018)

Tamoxifen Promotes Axonal Preservation and Gait Locomotion Recovery after Spinal Cord Injury in Cats
por: de la Torre Valdovinos, Braniff, et al.
Publicado: (2016)

Clemastine Enhances Myelination, Delays Axonal Loss and Promotes Functional Recovery in Spinal Cord Injury
por: Du, Weihong, et al.
Publicado: (2021)

Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury
por: Wang, Yi-Xin, et al.
Publicado: (2021)

Unc5B associates with LARG to mediate the action of repulsive guidance molecule
por: Hata, Katsuhiko, et al.
Publicado: (2009)

Potential roles of the RGMa-FAK-Ras pathway in hippocampal mossy fiber sprouting in the pentylenetetrazole kindling model
por: SONG, MING-YU, et al.
Publicado: (2015)

RGMa Participates in the Blood–Brain Barrier Dysfunction Through BMP/BMPR/YAP Signaling in Multiple Sclerosis
por: Zhang, Lei, et al.
Publicado: (2022)

Increase in repulsive guidance molecule-a (RGMa) in lacunar and cortical stroke patients is related to the severity of the insult
por: Parray, Aijaz, et al.
Publicado: (2022)

RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro
por: Yuan, Xiaofan, et al.
Publicado: (2022)

RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling
por: Sempert, Kai, et al.
Publicado: (2023)

Combinatory repair strategy to promote axon regeneration and functional recovery after chronic spinal cord injury
por: DePaul, Marc A., et al.
Publicado: (2017)

Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cord-injured mice
por: Shigyo, Michiko, et al.
Publicado: (2016)

Long-Distance Axon Regeneration Promotes Recovery of Diaphragmatic Respiratory Function after Spinal Cord Injury
por: Urban, Mark W., et al.
Publicado: (2019)

Pigment Epithelium-Derived Factor Promotes Axon Regeneration and Functional Recovery After Spinal Cord Injury
por: Stevens, Andrew R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_sankda3us5ji5m5s0jk1i4vgd4