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Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors

It is commonly assumed that photoreceptor (PR) outer segment (OS) morphogenesis is reliant upon the presence of peripherin/rds, hereafter termed Rds. In this study, we demonstrate a differential requirement of Rds during rod and cone OS morphogenesis. In the absence of this PR-specific protein, rods...

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Autores principales: Farjo, Rafal, Skaggs, Jeff S., Nagel, Barbara A., Quiambao, Alexander B., Nash, Zack A., Fliesler, Steven J., Naash, Muna I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063789/
https://www.ncbi.nlm.nih.gov/pubmed/16585269
http://dx.doi.org/10.1083/jcb.200509036
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author Farjo, Rafal
Skaggs, Jeff S.
Nagel, Barbara A.
Quiambao, Alexander B.
Nash, Zack A.
Fliesler, Steven J.
Naash, Muna I.
author_facet Farjo, Rafal
Skaggs, Jeff S.
Nagel, Barbara A.
Quiambao, Alexander B.
Nash, Zack A.
Fliesler, Steven J.
Naash, Muna I.
author_sort Farjo, Rafal
collection PubMed
description It is commonly assumed that photoreceptor (PR) outer segment (OS) morphogenesis is reliant upon the presence of peripherin/rds, hereafter termed Rds. In this study, we demonstrate a differential requirement of Rds during rod and cone OS morphogenesis. In the absence of this PR-specific protein, rods do not form OSs and enter apoptosis, whereas cone PRs develop atypical OSs and are viable. Such OSs consist of dysmorphic membranous structures devoid of lamellae. These tubular OSs lack any stacked lamellae and have reduced phototransduction efficiency. The loss of Rds only appears to affect the shape of the OS, as the inner segment and connecting cilium remain intact. Furthermore, these structures fail to associate with the specialized extracellular matrix that surrounds cones, suggesting that Rds itself or normal OS formation is required for this interaction. This study provides novel insight into the distinct role of Rds in the OS development of rods and cones.
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spelling pubmed-20637892007-11-29 Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors Farjo, Rafal Skaggs, Jeff S. Nagel, Barbara A. Quiambao, Alexander B. Nash, Zack A. Fliesler, Steven J. Naash, Muna I. J Cell Biol Research Articles It is commonly assumed that photoreceptor (PR) outer segment (OS) morphogenesis is reliant upon the presence of peripherin/rds, hereafter termed Rds. In this study, we demonstrate a differential requirement of Rds during rod and cone OS morphogenesis. In the absence of this PR-specific protein, rods do not form OSs and enter apoptosis, whereas cone PRs develop atypical OSs and are viable. Such OSs consist of dysmorphic membranous structures devoid of lamellae. These tubular OSs lack any stacked lamellae and have reduced phototransduction efficiency. The loss of Rds only appears to affect the shape of the OS, as the inner segment and connecting cilium remain intact. Furthermore, these structures fail to associate with the specialized extracellular matrix that surrounds cones, suggesting that Rds itself or normal OS formation is required for this interaction. This study provides novel insight into the distinct role of Rds in the OS development of rods and cones. The Rockefeller University Press 2006-04-10 /pmc/articles/PMC2063789/ /pubmed/16585269 http://dx.doi.org/10.1083/jcb.200509036 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Farjo, Rafal
Skaggs, Jeff S.
Nagel, Barbara A.
Quiambao, Alexander B.
Nash, Zack A.
Fliesler, Steven J.
Naash, Muna I.
Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title_full Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title_fullStr Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title_full_unstemmed Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title_short Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
title_sort retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063789/
https://www.ncbi.nlm.nih.gov/pubmed/16585269
http://dx.doi.org/10.1083/jcb.200509036
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