Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

We show that DNA double-strand breaks (DSBs) induce complex subcompartmentalization of genome surveillance regulators. Chromatin marked by γ-H2AX is occupied by ataxia telangiectasia–mutated (ATM) kinase, Mdc1, and 53BP1. In contrast, repair factors (Rad51, Rad52, BRCA2, and FANCD2), ATM and Rad-3–r...

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Detalles Bibliográficos
Autores principales: Bekker-Jensen, Simon, Lukas, Claudia, Kitagawa, Risa, Melander, Fredrik, Kastan, Michael B., Bartek, Jiri, Lukas, Jiri
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063811/
https://www.ncbi.nlm.nih.gov/pubmed/16618811
http://dx.doi.org/10.1083/jcb.200510130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063811/
https://www.ncbi.nlm.nih.gov/pubmed/16618811
http://dx.doi.org/10.1083/jcb.200510130

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