Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Loss of tuberin, the product of TSC2 gene, increases mammalian target of rapamycin (mTOR) signaling, promoting cell growth and tumor development. However, in cells expressing tuberin, it is not known how repression of mTOR signaling is relieved to activate this pathway in response to growth factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Sheng-Li, Tee, Andrew R., Short, John D., Bergeron, Judith M., Kim, Jinhee, Shen, Jianjun, Guo, Ruifeng, Johnson, Charles L., Kiguchi, Kaoru, Walker, Cheryl Lyn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063818/
https://www.ncbi.nlm.nih.gov/pubmed/16636147
http://dx.doi.org/10.1083/jcb.200507119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063818/
https://www.ncbi.nlm.nih.gov/pubmed/16636147
http://dx.doi.org/10.1083/jcb.200507119

Ejemplares similares