Optimization of WAVE2 complex–induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac

WAVE2 activates the actin-related protein (Arp) 2/3 complex for Rac-induced actin polymerization during lamellipodium formation and exists as a large WAVE2 protein complex with Sra1/PIR121, Nap1, Abi1, and HSPC300. IRSp53 binds to both Rac and Cdc42 and is proposed to link Rac to WAVE2. We found tha...

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Detalles Bibliográficos
Autores principales: Suetsugu, Shiro, Kurisu, Shusaku, Oikawa, Tsukasa, Yamazaki, Daisuke, Oda, Atsushi, Takenawa, Tadaomi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063866/
https://www.ncbi.nlm.nih.gov/pubmed/16702231
http://dx.doi.org/10.1083/jcb.200509067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063866/
https://www.ncbi.nlm.nih.gov/pubmed/16702231
http://dx.doi.org/10.1083/jcb.200509067

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