Cargando…

Axons break in animals lacking β-spectrin

Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. Breakage is caus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hammarlund, Marc, Jorgensen, Erik M., Bastiani, Michael J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063953/ https://www.ncbi.nlm.nih.gov/pubmed/17261846 http://dx.doi.org/10.1083/jcb.200611117

Ejemplares similares

Mutations in β-Spectrin Disrupt Axon Outgrowth and Sarcomere Structure
por: Hammarlund, Marc, et al.
Publicado: (2000)

Membrane domain organization of myelinated axons requires βII spectrin
por: Zhang, Chuansheng, et al.
Publicado: (2013)

Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration
por: Wang, Guiping, et al.
Publicado: (2019)

Axonal spectrins: All-purpose fences
por: Eshed-Eisenbach, Yael, et al.
Publicado: (2013)

Nodal β spectrins are required to maintain Na(+) channel clustering and axon integrity
por: Liu, Cheng-Hsin, et al.
Publicado: (2020)

βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System
por: Berghs, Stanny, et al.
Publicado: (2000)

βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
por: Yang, Yang, et al.
Publicado: (2007)

βIVΣ1 spectrin stabilizes the nodes of Ranvier and axon initial segments
por: Lacas-Gervais, Sandra, et al.
Publicado: (2004)

Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration
por: Coakley, Sean, et al.
Publicado: (2020)

Axonal Spectrins: Nanoscale Organization, Functional Domains and Spectrinopathies
por: Liu, Cheng-Hsin, et al.
Publicado: (2019)

Developmental Changes in Expression of βIV Spectrin Splice Variants at Axon Initial Segments and Nodes of Ranvier
por: Yoshimura, Takeshi, et al.
Publicado: (2017)

Mechanical Control of the Sense of Touch by β Spectrin
por: Krieg, Michael, et al.
Publicado: (2014)

αII-spectrin and βII-spectrin do not affect TGFβ1-induced myofibroblast differentiation
por: Piersma, Bram, et al.
Publicado: (2018)

The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton
por: Dubreuil, Ronald R, et al.
Publicado: (2010)

The axonal actin-spectrin lattice acts as a tension buffering shock absorber
por: Dubey, Sushil, et al.
Publicado: (2020)

βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier
por: Komada, Masayuki, et al.
Publicado: (2002)

Quantitative expansion microscopy for the characterization of the spectrin periodic skeleton of axons using fluorescence microscopy
por: Martínez, Gaby F., et al.
Publicado: (2020)

Drosophila β Spectrin Functions Independently of α Spectrin to Polarize the Na,k Atpase in Epithelial Cells
por: Dubreuil, Ronald R., et al.
Publicado: (2000)

Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling
por: Krieg, Michael, et al.
Publicado: (2017)

Non-erythroid beta spectrin interacting proteins and their effects on spectrin tetramerization
por: Sevinc, Akin, et al.
Publicado: (2011)

Muscle and epidermal contributions of the structural protein β-spectrin promote hypergravity-induced motor neuron axon defects in C. elegans
por: Kalichamy, Saraswathi S., et al.
Publicado: (2020)

Spectrin functions upstream of ankyrin in a spectrin cytoskeleton assembly pathway
por: Das, Amlan, et al.
Publicado: (2006)

Aberrant information transfer interferes with functional axon regeneration
por: Ding, Chen, et al.
Publicado: (2018)

Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila
por: Lorenzo, Damaris N., et al.
Publicado: (2010)

Spectrin is peripheral
por: Bonetta, Laura
Publicado: (2005)

Avian lens spectrin: subunit composition compared with erythrocyte and brain spectrin
Publicado: (1983)

Nuclear functions of β2-Spectrin in genomic stability
por: Mujoo, Kalpana, et al.
Publicado: (2016)

β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis
por: Silva, Ana Marta, et al.
Publicado: (2022)

β2-spectrin depletion impairs DNA damage repair
por: Horikoshi, Nobuo, et al.
Publicado: (2016)

Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
por: Khazma, Tami, et al.
Publicado: (2023)

rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans
por: Lin-Moore, Alexander T., et al.
Publicado: (2021)

β spectrin-dependent and domain specific mechanisms for Na(+) channel clustering
por: Liu, Cheng-Hsin, et al.
Publicado: (2020)

Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex
Publicado: (1994)

Beta spectrin bestows protein 4.1 sensitivity on spectrin-actin interactions
Publicado: (1987)

Role of Spectrin in Endocytosis
por: Li, Donghai
Publicado: (2022)

The Actin Binding Domain of βI-Spectrin Regulates the Morphological and Functional Dynamics of Dendritic Spines
por: Nestor, Michael W., et al.
Publicado: (2011)

αI-spectrin represents evolutionary optimization of spectrin for red blood cell deformability
por: Hale, John, et al.
Publicado: (2021)

The Spread of Spectrin in Ataxia and Neurodegenerative Disease
por: Morrow, Jon S., et al.
Publicado: (2021)

Brain spectrin(240/235) and brain spectrin(240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells
Publicado: (1986)

T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B
por: Garcia-Caballero, Agustin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ueomqg3q5gu9rq4hoqc45r24kc