Human and murine granzyme B exhibit divergent substrate preferences

The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization. Although human and mouse forms of GzmB e...

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Detalles Bibliográficos
Autores principales: Cullen, Sean P., Adrain, Colin, Lüthi, Alexander U., Duriez, Patrick J., Martin, Seamus J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063979/
https://www.ncbi.nlm.nih.gov/pubmed/17283187
http://dx.doi.org/10.1083/jcb.200612025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063979/
https://www.ncbi.nlm.nih.gov/pubmed/17283187
http://dx.doi.org/10.1083/jcb.200612025

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