DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

Cleavage of Notch by furin is required to generate a mature, cell surface heterodimeric receptor that can be proteolytically activated to release its intracellular domain, which functions in signal transduction. Current models propose that ligand binding to heterodimeric Notch (hNotch) induces a dis...

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Detalles Bibliográficos
Autores principales: Nichols, James T., Miyamoto, Alison, Olsen, Samantha L., D'Souza, Brendan, Yao, Christine, Weinmaster, Gerry
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063980/
https://www.ncbi.nlm.nih.gov/pubmed/17296795
http://dx.doi.org/10.1083/jcb.200609014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063980/
https://www.ncbi.nlm.nih.gov/pubmed/17296795
http://dx.doi.org/10.1083/jcb.200609014

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