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Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150(Glued), ORP1L, and the receptor βlll spectrin

The small GTPase Rab7 controls late endocytic transport by the minus end–directed motor protein complex dynein–dynactin, but how it does this is unclear. Rab7-interacting lysosomal protein (RILP) and oxysterol-binding protein–related protein 1L (ORP1L) are two effectors of Rab7. We show that GTP-bou...

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Detalles Bibliográficos
Autores principales: Johansson, Marie, Rocha, Nuno, Zwart, Wilbert, Jordens, Ingrid, Janssen, Lennert, Kuijl, Coenraad, Olkkonen, Vesa M., Neefjes, Jacques
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063981/
https://www.ncbi.nlm.nih.gov/pubmed/17283181
http://dx.doi.org/10.1083/jcb.200606077