Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

The multifunctional cytokine transforming growth factor (TGF) β1 is secreted in a latent complex with its processed propeptide (latency-associated peptide [LAP]). TGFβ1 must be functionally released from this complex before it can engage TGFβ receptors. One mechanism of latent TGFβ1 activation invol...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Zhiwei, Mu, Zhenyu, Dabovic, Branka, Jurukovski, Vladimir, Yu, Dawen, Sung, Joanne, Xiong, Xiaozhong, Munger, John S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064053/
https://www.ncbi.nlm.nih.gov/pubmed/17353357
http://dx.doi.org/10.1083/jcb.200611044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064053/
https://www.ncbi.nlm.nih.gov/pubmed/17353357
http://dx.doi.org/10.1083/jcb.200611044

Ejemplares similares