Cargando…

Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice

The multifunctional cytokine transforming growth factor (TGF) β1 is secreted in a latent complex with its processed propeptide (latency-associated peptide [LAP]). TGFβ1 must be functionally released from this complex before it can engage TGFβ receptors. One mechanism of latent TGFβ1 activation invol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Zhiwei, Mu, Zhenyu, Dabovic, Branka, Jurukovski, Vladimir, Yu, Dawen, Sung, Joanne, Xiong, Xiaozhong, Munger, John S.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064053/ https://www.ncbi.nlm.nih.gov/pubmed/17353357 http://dx.doi.org/10.1083/jcb.200611044

Ejemplares similares

Bone abnormalities in latent TGF-β binding protein (Ltbp)-3–null mice indicate a role for Ltbp-3 in modulating TGF-β bioavailability
por: Dabovic, Branka, et al.
Publicado: (2002)

Integrin α(V)β(6)-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
por: Annes, Justin P., et al.
Publicado: (2004)

The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1
por: Mu, Dezhi, et al.
Publicado: (2002)

TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
por: van Caam, A., et al.
Publicado: (2020)

TGFβ(1 )signaling via α(V)β(6 )integrin
por: Kracklauer, Martin P, et al.
Publicado: (2003)

Retraction: TGFβ(1 )signaling via a(V)β(6 )integrin
por: Kracklauer, Martin P, et al.
Publicado: (2004)

The role of integrins in TGFβ activation in the tumour stroma
por: Khan, Zareen, et al.
Publicado: (2016)

Premature Senescence and Increased TGFβ Signaling in the Absence of Tgif1
por: Zerlanko, Brad J., et al.
Publicado: (2012)

RECK-Mediated β1-Integrin Regulation by TGF-β1 Is Critical for Wound Contraction in Mice
por: Gutiérrez, Jaime, et al.
Publicado: (2015)

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation
por: Selvamurugan, Nagarajan, et al.
Publicado: (2017)

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
por: Parvani, Jenny G., et al.
Publicado: (2013)

New tools to study the interaction between integrins and latent TGFβ1
por: Bachmann, Michael, et al.
Publicado: (2023)

Fortilin interacts with TGF-β1 and prevents TGF-β receptor activation
por: Pinkaew, Decha, et al.
Publicado: (2022)

TGFβ(1 )activates c-Jun and Erk1 via α(V)β(6 )integrin
por: Luettich, Karsta, et al.
Publicado: (2003)

Correction for Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
Publicado: (2014)

Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8)
por: Duan, Zelin, et al.
Publicado: (2022)

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
por: Brown, Nicholas F., et al.
Publicado: (2019)

Role of TGF-β 1 and TGF-β Type II Receptor in Gastric Cancer
por: Park, Dong Il, et al.
Publicado: (2002)

TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
por: Dropmann, Anne, et al.
Publicado: (2016)

Generation of Pathogenic Th17 Cells in the Absence of TGF-β Signaling
por: Ghoreschi, Kamran, et al.
Publicado: (2010)

β3 Integrin Promotes TGF-β1/H(2)O(2)/HOCl-Mediated Induction of Metastatic Phenotype of Hepatocellular Carcinoma Cells by Enhancing TGF-β1 Signaling
por: Feng, Xin-Xia, et al.
Publicado: (2013)

Retraction: TGFβ(1 )activates c-Jun and Erk1 via a(V)β(6 )integrin
por: Luettich, Karsta, et al.
Publicado: (2004)

Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses
por: Meyers, Jordan M., et al.
Publicado: (2018)

Inhibition of Integrin αvβ6 Activation of TGF‐β Attenuates Tendinopathy
por: Wang, Xiao, et al.
Publicado: (2022)

Assessment of the effect of potential antifibrotic compounds on total and αVβ6 integrin‐mediated TGF‐β activation
por: Porte, Joanne, et al.
Publicado: (2014)

Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain
por: Hirota, Shinya, et al.
Publicado: (2015)

Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2
por: Mia, Md Saimon, et al.
Publicado: (2021)

Role and clinical significance of TGF-β1 and TGF-βR1 in malignant tumors (Review)
por: Wang, Junmin, et al.
Publicado: (2021)

Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus
por: Xu, Yinglei, et al.
Publicado: (2020)

Is Serum TGF-β1 and TGF-β2 levels Correlated to Children with Autism Intensity?
por: YOUSEFI, Jamshid, et al.
Publicado: (2021)

TGF-β1 and TGFβR2 Gene Polymorphisms in Patients with Unstable Angina
por: Malinowski, Damian, et al.
Publicado: (2023)

The Transforming Growth Factor-β1 (TGF-β1) Gene Polymorphisms (TGF-β1 T869C and TGF-β1 T29C) and Susceptibility to Postmenopausal Osteoporosis: A Meta-Analysis
por: Sun, Jiajia, et al.
Publicado: (2015)

Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells
por: Kang, Seung G., et al.
Publicado: (2010)

BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein
por: Ge, Gaoxiang, et al.
Publicado: (2006)

αvβ3 Integrin induces partial EMT independent of TGF-β signaling
por: Kariya, Yoshinobu, et al.
Publicado: (2021)

Radial glia promote microglial development through integrin α(V)β(8) -TGFβ1 signaling
por: McKinsey, Gabriel L., et al.
Publicado: (2023)

Data on the TGFβ response of CD4(+) T cells in the absence of Eed
por: Naito, Taku, et al.
Publicado: (2018)

Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium
por: Flanders, Kathleen C., et al.
Publicado: (2016)

TGF-β-activated kinase-1: New insights into the mechanism of TGF-β signaling and kidney disease
por: Kim, Sung Il, et al.
Publicado: (2012)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_egj1nrnbpvc3hbnlelc6ru81l9