Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

Spastin, an AAA ATPase mutated in the neurodegenerative disease hereditary spastic paraplegia, severs microtubules. Many other AAA proteins form ring-shaped hexamers and contain pore loops, which project into the ring's central cavity and act as ratchets that pull on target proteins, leading, i...

Descripción completa

Detalles Bibliográficos
Autores principales: White, Susan Roehl, Evans, Katia J., Lary, Jeffrey, Cole, James L., Lauring, Brett
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064084/
https://www.ncbi.nlm.nih.gov/pubmed/17389232
http://dx.doi.org/10.1083/jcb.200610072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064084/
https://www.ncbi.nlm.nih.gov/pubmed/17389232
http://dx.doi.org/10.1083/jcb.200610072

Ejemplares similares