PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins

The pathogenesis of spinocerebellar ataxia type 7 and other neurodegenerative polyglutamine (polyQ) disorders correlates with the aberrant accumulation of toxic polyQ-expanded proteins in the nucleus. Promyelocytic leukemia protein (PML) nuclear bodies are often present in polyQ aggregates, but thei...

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Detalles Bibliográficos
Autores principales: Janer, Alexandre, Martin, Elodie, Muriel, Marie-Paule, Latouche, Morwena, Fujigasaki, Hiroto, Ruberg, Merle, Brice, Alexis, Trottier, Yvon, Sittler, Annie
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064165/
https://www.ncbi.nlm.nih.gov/pubmed/16818720
http://dx.doi.org/10.1083/jcb.200511045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064165/
https://www.ncbi.nlm.nih.gov/pubmed/16818720
http://dx.doi.org/10.1083/jcb.200511045

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