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PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins

The pathogenesis of spinocerebellar ataxia type 7 and other neurodegenerative polyglutamine (polyQ) disorders correlates with the aberrant accumulation of toxic polyQ-expanded proteins in the nucleus. Promyelocytic leukemia protein (PML) nuclear bodies are often present in polyQ aggregates, but thei...

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Detalles Bibliográficos
Autores principales:	Janer, Alexandre, Martin, Elodie, Muriel, Marie-Paule, Latouche, Morwena, Fujigasaki, Hiroto, Ruberg, Merle, Brice, Alexis, Trottier, Yvon, Sittler, Annie
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2006
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064165/ https://www.ncbi.nlm.nih.gov/pubmed/16818720 http://dx.doi.org/10.1083/jcb.200511045

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