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Bim(S)-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

Release of apoptogenic proteins such as cytochrome c from mitochondria is regulated by pro- and anti-apoptotic Bcl-2 family proteins, with pro-apoptotic BH3-only proteins activating Bax and Bak. Current models assume that apoptosis induction occurs via the binding and inactivation of anti-apoptotic...

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Detalles Bibliográficos
Autores principales:	Weber, Arnim, Paschen, Stefan A., Heger, Klaus, Wilfling, Florian, Frankenberg, Tobias, Bauerschmitt, Heike, Seiffert, Barbara M., Kirschnek, Susanne, Wagner, Hermann, Häcker, Georg
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064208/ https://www.ncbi.nlm.nih.gov/pubmed/17517961 http://dx.doi.org/10.1083/jcb.200610148

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