Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1

Protease-activated receptor-1 (PAR1), a G protein–coupled receptor (GPCR) for thrombin, is irreversibly activated by proteolysis. Consequently, PAR1 trafficking is critical for the fidelity of thrombin signaling. PAR1 displays constitutive and agonist-induced internalization, which are clathrin and...

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Detalles Bibliográficos
Autores principales: Wolfe, Breann L., Marchese, Adriano, Trejo, JoAnn
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064289/
https://www.ncbi.nlm.nih.gov/pubmed/17535965
http://dx.doi.org/10.1083/jcb.200610154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064289/
https://www.ncbi.nlm.nih.gov/pubmed/17535965
http://dx.doi.org/10.1083/jcb.200610154

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