YGR198w (YPP1) targets A30P α-synuclein to the vacuole for degradation

Using a genetic screen we discovered that YGR198w (named YPP1), which is an essential Saccharomyces cerevisiae gene of unknown function, suppresses the toxicity of an α-synuclein (α-syn) mutant (A30P) that is associated with early onset Parkinson's disease. Here, we show that YPP1 suppresses le...

Descripción completa

Detalles Bibliográficos
Autores principales: Flower, Todd R., Clark-Dixon, Cheryl, Metoyer, Cheynita, Yang, Hui, Shi, Runhua, Zhang, Zhaojie, Witt, Stephan N.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064368/
https://www.ncbi.nlm.nih.gov/pubmed/17576801
http://dx.doi.org/10.1083/jcb.200610071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064368/
https://www.ncbi.nlm.nih.gov/pubmed/17576801
http://dx.doi.org/10.1083/jcb.200610071

Ejemplares similares