BLM helicase–dependent and –independent roles of 53BP1 during replication stress–mediated homologous recombination

Mutations in BLM helicase cause Bloom syndrome, characterized by predisposition to all forms of cancer. We demonstrate that BLM, signal transducer 53BP1, and RAD51 interact during stalled replication. Interactions between the three proteins have functional consequences. Lack of 53BP1 decreases the c...

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Detalles Bibliográficos
Autores principales: Tripathi, Vivek, Nagarjuna, Tirunelvely, Sengupta, Sagar
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064412/
https://www.ncbi.nlm.nih.gov/pubmed/17591918
http://dx.doi.org/10.1083/jcb.200610051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064412/
https://www.ncbi.nlm.nih.gov/pubmed/17591918
http://dx.doi.org/10.1083/jcb.200610051

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