Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration

Two distinct Thr phosphorylation events within the cytoplasmic domain of the NG2 proteoglycan help regulate the cellular balance between proliferation and motility. Protein kinase Cα mediates the phosphorylation of NG2 at Thr(2256), resulting in enhanced cell motility. Extracellular signal–regulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Makagiansar, Irwan T., Williams, Scott, Mustelin, Tomas, Stallcup, William B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064431/
https://www.ncbi.nlm.nih.gov/pubmed/17591920
http://dx.doi.org/10.1083/jcb.200612084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064431/
https://www.ncbi.nlm.nih.gov/pubmed/17591920
http://dx.doi.org/10.1083/jcb.200612084

Ejemplares similares