An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

In vertebrates Cdk1 is required to initiate mitosis; however, any functionality of this kinase during S phase remains unclear. To investigate this, we generated chicken DT40 mutants, in which an analog-sensitive mutant cdk1 as replaces the endogenous Cdk1, allowing us to specifically inactivate Cdk1...

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Detalles Bibliográficos
Autores principales: Hochegger, Helfrid, Dejsuphong, Donniphat, Sonoda, Eiichiro, Saberi, Alihossein, Rajendra, Eeson, Kirk, Jane, Hunt, Tim, Takeda, Shunichi
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064445/
https://www.ncbi.nlm.nih.gov/pubmed/17635936
http://dx.doi.org/10.1083/jcb.200702034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064445/
https://www.ncbi.nlm.nih.gov/pubmed/17635936
http://dx.doi.org/10.1083/jcb.200702034

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