OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease s...

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Detalles Bibliográficos
Autores principales: Song, Zhiyin, Chen, Hsiuchen, Fiket, Maja, Alexander, Christiane, Chan, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064540/
https://www.ncbi.nlm.nih.gov/pubmed/17709429
http://dx.doi.org/10.1083/jcb.200704110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064540/
https://www.ncbi.nlm.nih.gov/pubmed/17709429
http://dx.doi.org/10.1083/jcb.200704110

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