Cargando…

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Zhiyin, Chen, Hsiuchen, Fiket, Maja, Alexander, Christiane, Chan, David C.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2007
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064540/ https://www.ncbi.nlm.nih.gov/pubmed/17709429 http://dx.doi.org/10.1083/jcb.200704110

Ejemplares similares

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
por: Anand, Ruchika, et al.
Publicado: (2014)

Loss of Yme1L perturbates mitochondrial dynamics
por: Ruan, Y, et al.
Publicado: (2013)

Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane
por: Ge, Yifan, et al.
Publicado: (2020)

GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L‐mediated OPA1 processing
por: Zhao, Yun, et al.
Publicado: (2020)

Mitochondrial inner-membrane protease Yme1 degrades outer-membrane proteins Tom22 and Om45
por: Wu, Xi, et al.
Publicado: (2018)

Characterization of two novel intronic OPA1 mutations resulting in aberrant pre-mRNA splicing
por: Bolognini, Ramona, et al.
Publicado: (2017)

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
por: Losón, Oliver C., et al.
Publicado: (2013)

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1
por: Ehses, Sarah, et al.
Publicado: (2009)

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1
por: Lee, Hakjoo, et al.
Publicado: (2018)

OPA1 and MICOS Regulate mitochondrial crista dynamics and formation
por: Hu, Chao, et al.
Publicado: (2020)

Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1
por: Spiller, Michael P., et al.
Publicado: (2015)

Understanding the Role of Yeast Yme1 in Mitochondrial Function Using Biochemical and Proteomics Analyses
por: Kan, Kwan Ting, et al.
Publicado: (2022)

Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases
por: Chen, Hsiuchen, et al.
Publicado: (2009)

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation
por: Hartmann, Bianca, et al.
Publicado: (2016)

OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion
por: Yang, Liang, et al.
Publicado: (2020)

Characterisation of a novel OPA1 splice variant resulting in cryptic splice site activation and mitochondrial dysfunction
por: Harvey, Joshua Paul, et al.
Publicado: (2022)

Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1
por: Ando, Koji, et al.
Publicado: (2019)

Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion
por: Wang, Ruohan, et al.
Publicado: (2021)

OPA1’s shortcut to mitochondrial fission
por: Short, Ben
Publicado: (2014)

L‐OPA1 regulates mitoflash biogenesis independently from membrane fusion
por: Rosselin, Manon, et al.
Publicado: (2017)

Knock-down of YME1L1 induces mitochondrial dysfunction during early porcine embryonic development
por: Zhou, Dongjie, et al.
Publicado: (2023)

The mitochondrial protein YME1 Like 1 is important for non-small cell lung cancer cell growth
por: Xia, Yingchen, et al.
Publicado: (2023)

Absence of Cardiolipin From the Outer Leaflet of a Mitochondrial Inner Membrane Mimic Restricts Opa1-Mediated Fusion
por: Ge, Yifan, et al.
Publicado: (2021)

Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy
por: Sprenger, Hans‐Georg, et al.
Publicado: (2018)

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation
por: Ban, Tadato, et al.
Publicado: (2010)

Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development
por: Rahn, Jennifer J., et al.
Publicado: (2013)

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
por: Li, Meng, et al.
Publicado: (2020)

Altered Mitochondrial Opa1-Related Fusion in Mouse Promotes Endothelial Cell Dysfunction and Atherosclerosis
por: Chehaitly, Ahmad, et al.
Publicado: (2022)

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion
por: Cartes-Saavedra, Benjamín, et al.
Publicado: (2023)

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol’s Anti-Tumor Angiogenesis Effect
por: Li, Gaofu, et al.
Publicado: (2022)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
por: Kieper, Nicole, et al.
Publicado: (2010)

Sirt3 mitigates LPS‐induced mitochondrial damage in renal tubular epithelial cells by deacetylating YME1L1
por: Jian, Yonghong, et al.
Publicado: (2022)

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria
por: Schreiner, Bernadette, et al.
Publicado: (2012)

Loss of Mitochondrial AAA Proteases AFG3L2 and YME1L Impairs Mitochondrial Structure and Respiratory Chain Biogenesis
por: Cesnekova, Jana, et al.
Publicado: (2018)

The Effect of OPA1 on Mitochondrial Ca(2+) Signaling
por: Fülöp, László, et al.
Publicado: (2011)

ThYme: a database for thioester-active enzymes
por: Cantu, David C., et al.
Publicado: (2011)

In situ architecture of Opa1-dependent mitochondrial cristae remodeling
por: Fry, Michelle Y., et al.
Publicado: (2023)

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway
por: Parra, Valentina, et al.
Publicado: (2014)

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
por: Chen, Hsiuchen, et al.
Publicado: (2003)

Fluorescence Methods Applied to the Description of Urea-Dependent YME1L Protease Unfolding
por: Moore, Sydney, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_aqq4ggm2fg942d8soahuhi35h4