A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop

Insulin-like growth factor 1 receptor (IGF-1R) is important in cancer cell growth and survival and has been implicated in cancer pathophysiology and treatment. Here we report a novel function for IGF-1R in p53-dependent apoptotic response. We show that inhibition or loss of IGF-1R activity reduces t...

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Detalles Bibliográficos
Autores principales: Xiong, Lei, Kou, Fei, Yang, Ying, Wu, Jiarui
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064623/
https://www.ncbi.nlm.nih.gov/pubmed/17846171
http://dx.doi.org/10.1083/jcb.200703044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064623/
https://www.ncbi.nlm.nih.gov/pubmed/17846171
http://dx.doi.org/10.1083/jcb.200703044

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