Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means that cells use to minimize misfolded protein-induced cytotoxicity. However, the molecular mechanism by which misfolded proteins are recruited to aggresomes remains unclear. Mutations in the E3 ligase park...

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Detalles Bibliográficos
Autores principales: Olzmann, James A., Li, Lian, Chudaev, Maksim V., Chen, Jue, Perez, Francisco A., Palmiter, Richard D., Chin, Lih-Shen
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064625/
https://www.ncbi.nlm.nih.gov/pubmed/17846173
http://dx.doi.org/10.1083/jcb.200611128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064625/
https://www.ncbi.nlm.nih.gov/pubmed/17846173
http://dx.doi.org/10.1083/jcb.200611128

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