BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin

Breast cancer–associated protein 1 (BRCA1) forms foci at sites of induced DNA damage, but any significance of these normal S-phase foci is unknown. BRCA1 distribution does not simply mirror or overlap that of replicating DNA; however, BRCA1 foci frequently abut sites of BrdU incorporation, mostly at...

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Detalles Bibliográficos
Autores principales: Pageau, Gayle J., Lawrence, Jeanne B.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064668/
https://www.ncbi.nlm.nih.gov/pubmed/17145961
http://dx.doi.org/10.1083/jcb.200602055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064668/
https://www.ncbi.nlm.nih.gov/pubmed/17145961
http://dx.doi.org/10.1083/jcb.200602055

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