Inhibition of Rho A activity causes pemphigus skin blistering

The autoimmune blistering skin diseases pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are mainly caused by autoantibodies against desmosomal cadherins. In this study, we provide evidence that PV–immunoglobulin G (IgG) and PF-IgG induce skin blistering by interference with Rho A signaling. In...

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Detalles Bibliográficos
Autores principales: Waschke, Jens, Spindler, Volker, Bruggeman, Paola, Zillikens, Detlef, Schmidt, Gudula, Drenckhahn, Detlev
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064672/
https://www.ncbi.nlm.nih.gov/pubmed/17130286
http://dx.doi.org/10.1083/jcb.200605125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064672/
https://www.ncbi.nlm.nih.gov/pubmed/17130286
http://dx.doi.org/10.1083/jcb.200605125

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