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Defective Ca(2+) channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy

Proximal spinal muscular atrophy (SMA) is a motoneuron disease for which there is currently no effective treatment. In animal models of SMA, spinal motoneurons exhibit reduced axon elongation and growth cone size. These defects correlate with reduced β-actin messenger RNA and protein levels in dista...

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Detalles Bibliográficos
Autores principales: Jablonka, Sibylle, Beck, Marcus, Lechner, Barbara Dorothea, Mayer, Christine, Sendtner, Michael
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064743/
https://www.ncbi.nlm.nih.gov/pubmed/17923533
http://dx.doi.org/10.1083/jcb.200703187