KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions

Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1 binds to Rap1, a guanosine triphosphatase that mai...

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Detalles Bibliográficos
Autores principales: Glading, Angela, Han, Jaewon, Stockton, Rebecca A., Ginsberg, Mark H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064761/
https://www.ncbi.nlm.nih.gov/pubmed/17954608
http://dx.doi.org/10.1083/jcb.200705175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064761/
https://www.ncbi.nlm.nih.gov/pubmed/17954608
http://dx.doi.org/10.1083/jcb.200705175

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