Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

The physiological role of the mitotic checkpoint protein Bub1 is unknown. To study this role, we generated a series of mutant mice with a gradient of reduced Bub1 expression using wild-type, hypomorphic, and knockout alleles. Bub1 hypomorphic mice are viable, fertile, and overtly normal despite weak...

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Detalles Bibliográficos
Autores principales: Jeganathan, Karthik, Malureanu, Liviu, Baker, Darren J., Abraham, Susan C., van Deursen, Jan M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064762/
https://www.ncbi.nlm.nih.gov/pubmed/17938250
http://dx.doi.org/10.1083/jcb.200706015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064762/
https://www.ncbi.nlm.nih.gov/pubmed/17938250
http://dx.doi.org/10.1083/jcb.200706015

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