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Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis
The physiological role of the mitotic checkpoint protein Bub1 is unknown. To study this role, we generated a series of mutant mice with a gradient of reduced Bub1 expression using wild-type, hypomorphic, and knockout alleles. Bub1 hypomorphic mice are viable, fertile, and overtly normal despite weak...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064762/ https://www.ncbi.nlm.nih.gov/pubmed/17938250 http://dx.doi.org/10.1083/jcb.200706015 |