Cargando…
Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres
Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomerase shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a direct impact of telomere length...
Autores principales: | Siegl-Cachedenier, Irene, Flores, Ignacio, Klatt, Peter, Blasco, Maria A. |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064764/ https://www.ncbi.nlm.nih.gov/pubmed/17954610 http://dx.doi.org/10.1083/jcb.200704141 |
Ejemplares similares
-
Reversibility of Defective Hematopoiesis Caused by Telomere Shortening in Telomerase Knockout Mice
por: Raval, Aparna, et al.
Publicado: (2015) -
ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
por: McNees, Carolyn J., et al.
Publicado: (2010) -
A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres
por: Flores, Ignacio, et al.
Publicado: (2009) -
Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres
por: Povedano, Juan Manuel, et al.
Publicado: (2018) -
Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice
por: Whittemore, Kurt, et al.
Publicado: (2019)