O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

The effect of the O6-alkylguanine-DNA alkyltransferase (AGT) inhibitor, O6-benzylguanine (O6-BG), on the anti-tumour activity of 8-carbamoyl-3-methylimidazo [5,1-d]-1,2,3,5-tetrazine-4(3H)-one (temozolomide) or 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) was evaluated in athymic mice bearing subcutane...

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Detalles Bibliográficos
Autores principales: Wedge, S. R., Newlands, E. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074397/
https://www.ncbi.nlm.nih.gov/pubmed/8624262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074397/
https://www.ncbi.nlm.nih.gov/pubmed/8624262

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