Activation of methotrexate-phenylalanine by monoclonal antibody--carboxypeptidase A conjugate for the specific treatment of ovarian cancer in vitro.

Monoclonal antibody 4E3 directed against a glycosylated surface protein on human ovarian teratocarcinoma cells (CRL-1572 cell line) was conjugated to bovine carboxypeptidase A (CPA) using a 3400 Da polyethylene glycol chain bearing an N-hydroxysuccinimide group at both ends. The conjugate preparatio...

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Detalles Bibliográficos
Autores principales: Perron, M. J., Page, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074434/
https://www.ncbi.nlm.nih.gov/pubmed/8562331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074434/
https://www.ncbi.nlm.nih.gov/pubmed/8562331

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