Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.

Depletion of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT) with O(6)-benzylguanine (O(6)-BG) has been widely shown to enhance 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) activity. This study aimed to determine whether temozolomide, a methylating imidazotetrazinone, would similarl...

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Detalles Bibliográficos
Autores principales: Wedge, S. R., Porteus, J. K., May, B. L., Newlands, E. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074446/
https://www.ncbi.nlm.nih.gov/pubmed/8595163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074446/
https://www.ncbi.nlm.nih.gov/pubmed/8595163

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