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The chronic administration of drugs that inhibit the regulation of intracellular pH: in vitro and anti-tumour effects.

Mean values of extracellular pH (pHe) in tumours tend to be about 0.5 pH units lower than in normal tissues, whereas values of intracellular pH (pHi) in tumours and normal tissues are similar. Previous studies have shown that drugs that acidify cells at lower pHe such as nigericin, used alone or wit...

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Detalles Bibliográficos
Autores principales: Yamagata, M., Tannock, I. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074490/
https://www.ncbi.nlm.nih.gov/pubmed/8645575