A constitutional de novo mutation in exon 8 of the p53 gene in a patient with multiple primary malignancies.

We report a constitutional point mutation of codon 278 in exon 8 of the TP53 gene that has not yet been described as a germ-line mutation. A 52-year-old female developed multiple primary malignancies (liposarcoma, breast cancer, malignant histiocytoma, occult adenocarcinoma). The mutation found in h...

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Detalles Bibliográficos
Autores principales: Speiser, P., Gharehbaghi-Schnell, E., Eder, S., Haid, A., Kovarík, J., Nenutil, R., Sauter, G., Schneeberger, C. H., Vojtesek, B., Wiltschke, C. H., Zeillinger, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074589/
https://www.ncbi.nlm.nih.gov/pubmed/8688334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074589/
https://www.ncbi.nlm.nih.gov/pubmed/8688334

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