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Recurrences and related characteristics of gastric cancer.

We analysed data on 1117 patients with gastric cancer who were treated by curative resection. Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour l...

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Autores principales: Maehara, Y., Emi, Y., Baba, H., Adachi, Y., Akazawa, K., Ichiyoshi, Y., Sugimachi, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074740/
https://www.ncbi.nlm.nih.gov/pubmed/8826869
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author Maehara, Y.
Emi, Y.
Baba, H.
Adachi, Y.
Akazawa, K.
Ichiyoshi, Y.
Sugimachi, K.
author_facet Maehara, Y.
Emi, Y.
Baba, H.
Adachi, Y.
Akazawa, K.
Ichiyoshi, Y.
Sugimachi, K.
author_sort Maehara, Y.
collection PubMed
description We analysed data on 1117 patients with gastric cancer who were treated by curative resection. Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour location, tumour tissue differentiation, growth pattern, depth of invasion, lymphatic and vascular invasion and lymph node metastasis. In proportion to the growth potential, determined by the level of proliferating cell nuclear antigen (PCNA) labelling, the death related to a recurrence was increased and the prognosis was poorer. Multivariate analysis showed that the three factors of serosal invasion, PCNA labelling index and lymph node dissection were independent prognostic factors. When sites of recurrence were analysed regarding each depth of invasion, haematogenous recurrence, in particular in the liver, occurred even in cases of an early invasion and many types of recurrences, including peritoneal recurrence, were noted in patients with an advanced state of invasion.
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spelling pubmed-20747402009-09-10 Recurrences and related characteristics of gastric cancer. Maehara, Y. Emi, Y. Baba, H. Adachi, Y. Akazawa, K. Ichiyoshi, Y. Sugimachi, K. Br J Cancer Research Article We analysed data on 1117 patients with gastric cancer who were treated by curative resection. Attention was focused on invasion and a recurrence of the cancer. Based on a univariate analysis, death following a recurrence and prognosis were related to age of the patients, size of the tumour, tumour location, tumour tissue differentiation, growth pattern, depth of invasion, lymphatic and vascular invasion and lymph node metastasis. In proportion to the growth potential, determined by the level of proliferating cell nuclear antigen (PCNA) labelling, the death related to a recurrence was increased and the prognosis was poorer. Multivariate analysis showed that the three factors of serosal invasion, PCNA labelling index and lymph node dissection were independent prognostic factors. When sites of recurrence were analysed regarding each depth of invasion, haematogenous recurrence, in particular in the liver, occurred even in cases of an early invasion and many types of recurrences, including peritoneal recurrence, were noted in patients with an advanced state of invasion. Nature Publishing Group 1996-09 /pmc/articles/PMC2074740/ /pubmed/8826869 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Maehara, Y.
Emi, Y.
Baba, H.
Adachi, Y.
Akazawa, K.
Ichiyoshi, Y.
Sugimachi, K.
Recurrences and related characteristics of gastric cancer.
title Recurrences and related characteristics of gastric cancer.
title_full Recurrences and related characteristics of gastric cancer.
title_fullStr Recurrences and related characteristics of gastric cancer.
title_full_unstemmed Recurrences and related characteristics of gastric cancer.
title_short Recurrences and related characteristics of gastric cancer.
title_sort recurrences and related characteristics of gastric cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2074740/
https://www.ncbi.nlm.nih.gov/pubmed/8826869
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