Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.

Biopsies from 61 sporadic metastatic malignant melanomas and five melanoma cell lines were examined for homozygous deletions and mutations in the CDKN2 gene (p16). As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also...

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Detalles Bibliográficos
Autores principales: Maelandsmo, G. M., Flørenes, V. A., Hovig, E., Oyjord, T., Engebraaten, O., Holm, R., Børresen, A. L., Fodstad, O.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075830/
https://www.ncbi.nlm.nih.gov/pubmed/8611425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2075830/
https://www.ncbi.nlm.nih.gov/pubmed/8611425

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