3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity.

O6-benzylguanine (O6-BG) and 3-aminobenzamide (3-AB) inhibit the DNA repair proteins O6-alkylguanine-DNA alkyltransferase (AGT) and poly(ADP-ribose) polymerase (PARP) respectively. The effect of O6-BG and/or 3-AB on temozolomide and 1,3-bis(2-chloroethyl)-nitrosourea (BCNU) cytotoxicity, was assesse...

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Detalles Bibliográficos
Autores principales: Wedge, S. R., Porteous, J. K., Newlands, E. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077105/
https://www.ncbi.nlm.nih.gov/pubmed/8855970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077105/
https://www.ncbi.nlm.nih.gov/pubmed/8855970

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