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LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms

BACKGROUND: IL-10 is a cytokine mainly produced by macrophages that plays key roles in tolerance to inhaled antigens and in lung homeostasis. Its regulation in alveolar macrophages (HAM), the resident lung phagocytes, remains however unknown. METHODS: The present study investigated the role of intra...

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Detalles Bibliográficos
Autores principales: Chanteux, Hugues, Guisset, Amélie C, Pilette, Charles, Sibille, Yves
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080632/
https://www.ncbi.nlm.nih.gov/pubmed/17916230
http://dx.doi.org/10.1186/1465-9921-8-71