C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice

C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus autoantigens. However, the role of C1q in the regulation of autoreactive B cells remains debatable. To explore this we crossed MRL/Mp C1q-deficient mi...

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Detalles Bibliográficos
Autores principales: Fossati-Jimack, Liliane, Cortes-Hernandez, Josefina, Norsworthy, Peter J., Walport, Mark J., Cook, H. Terence, Botto, Marina
Formato: Texto
Lenguaje:English
Publicado: Pergamon Press 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080686/
https://www.ncbi.nlm.nih.gov/pubmed/17675234
http://dx.doi.org/10.1016/j.molimm.2007.06.162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080686/
https://www.ncbi.nlm.nih.gov/pubmed/17675234
http://dx.doi.org/10.1016/j.molimm.2007.06.162

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