Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice

BACKGROUND: The HIV-1 maturation inhibitor, 3-O-(3′,3′-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity against multiple wild-type (WT) and drug-resistant HIV-1 isolates. Bevirimat has a novel mechanism of action, specifically...

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Detalles Bibliográficos
Autores principales: Stoddart, Cheryl A., Joshi, Pheroze, Sloan, Barbara, Bare, Jennifer C., Smith, Philip C., Allaway, Graham P., Wild, Carl T., Martin, David E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080775/
https://www.ncbi.nlm.nih.gov/pubmed/18043758
http://dx.doi.org/10.1371/journal.pone.0001251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080775/
https://www.ncbi.nlm.nih.gov/pubmed/18043758
http://dx.doi.org/10.1371/journal.pone.0001251

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