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DAF-2/Insulin-Like Signaling in C. elegans Modifies Effects of Dietary Restriction and Nutrient Stress on Aging, Stress and Growth

BACKGROUND: Dietary restriction (DR) and reduced insulin/IGF-I-like signaling (IIS) are two regimens that promote longevity in a variety of organisms. Genetic analysis in C. elegans nematodes has shown that DR and IIS couple to distinct cellular signaling pathways. However, it is not known whether t...

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Detalles Bibliográficos
Autores principales: Iser, Wendy B., Wolkow, Catherine A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080776/
https://www.ncbi.nlm.nih.gov/pubmed/18043747
http://dx.doi.org/10.1371/journal.pone.0001240