The ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted

DNA replication in eukaryotic cells is tightly controlled by a licensing mechanism, ensuring that each origin fires once and only once per cell cycle. We demonstrate that the ataxia telangiectasia and Rad3 related (ATR)–mediated S phase checkpoint acts as a surveillance mechanism to prevent rereplic...

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Detalles Bibliográficos
Autores principales: Liu, Enbo, Lee, Alan Yueh-Luen, Chiba, Takuya, Olson, Erin, Sun, Peiqing, Wu, Xiaohua
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080923/
https://www.ncbi.nlm.nih.gov/pubmed/18025301
http://dx.doi.org/10.1083/jcb.200704138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080923/
https://www.ncbi.nlm.nih.gov/pubmed/18025301
http://dx.doi.org/10.1083/jcb.200704138

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